SPHINGOSINE-1-PHOSPHATE SECRETS

Lower concentrations of S1P are chemotactic for osteoclast precursors, when high concentrations inhibit their motion seventy nine. This means that these precursors, which Categorical both equally S1PR1 and S1PR2, are kept during the vicinity in the bone because of the S1P gradient: S1PR2 prevents S1PR1-induced migration of those bone-resorbing cell